Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments
Harbin Medical University · Third Affiliated Hospital of Harbin Medical University · +4 more institutions
Abstract
The malignant tumor is a multi-etiological, systemic and complex disease characterized by uncontrolled cell proliferation and distant metastasis. Anticancer treatments including adjuvant therapies and targeted therapies are effective in eliminating cancer cells but in a limited number of patients. Increasing evidence suggests that the extracellular matrix (ECM) plays an important role in tumor development through changes in macromolecule components, degradation enzymes and stiffness. These variations are under the control of cellular components in tumor tissue via the aberrant activation of signaling pathways, the interaction of the ECM components to multiple surface receptors, and mechanical impact.…
Citation impact
- FWCI
- 198.15
- Percentile
- 100%
- References
- 635
Authors
9- ZYZhennan Yuan
Harbin Medical University, Third Affiliated Hospital of Harbin Medical University
- YLYingpu Li
Harbin Medical University, Third Affiliated Hospital of Harbin Medical University
- SZSifan Zhang
Harbin Medical University
- XWXueying Wang
Central South University, Xiangya Hospital Central South University
- HDHe Dou
Harbin Medical University, Third Affiliated Hospital of Harbin Medical University
Topics & keywords
- Extracellular matrix
- Biology
- Immune system
- Extracellular
- Cell biology
- Cancer research
- Tumor microenvironment
- Tumor progression
- Good health and well-being