Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS/HO-1/GPX4 axis

Lin, Qisheng; Li, Shu; Jin, Haijiao; Cai, Hong; Zhu, Xuying; Yang, Yuanting; Wu, Jingkui; Qi, Chaojun; Shao, Xinghua; Li, Jialin; Zhang, Kaiqi; Zhou, Wenyan; Zhang, Minfang; Cheng, Jiayi; Gu, Leyi; Mou, Shan; Ni, Zhaohui

doi:10.7150/ijbs.80775

articleInternational Journal of Biological SciencesJan 1, 2023GOLD OA

Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS/HO-1/GPX4 axis

QLQisheng Lin SLShu Li HJHaijiao Jin HCHong Cai XZXuying Zhu

Shanghai Jiao Tong University

PubMed

Indexed incrossrefdoajpubmed

Abstract

Knockout cisplatin-treated mice. Ferrstatin-1, a synthetic antioxidative ferroptosis inhibitor, rescued iron accumulation, lipid peroxidation and ferroptosis caused by inhibition of mitophagy. Thus, the present study elucidated a novel mechanism by which both BNIP3-mediated and PINK1-PARK2-mediated mitophagy protects against cisplatin-induced renal tubular epithelial cell ferroptosis through the ROS/HO1/GPX4 axis.

Citation impact

215

total citations

FWCI: 52.02
Percentile: 100%
References: 69

Citations per year

Authors

17

Topics & keywords

Topics

Keywords

Mitophagy
Lipid peroxidation
PINK1
Cell biology
Programmed cell death
GPX4
Chemistry
Cisplatin

UN Sustainable Development Goals

Good health and well-being

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