articleAdvanced MaterialsMar 14, 2023BRONZE OA

Bioinspired Adaptable Indwelling Microneedles for Treatment of Diabetic Ulcers

XZXiaoxuan ZhangJGJingjing GanLFLu FanZLZhiqiang LuoYZYuanjin Zhao

Nanjing Drum Tower Hospital · Southeast University · +3 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Microneedles provide an effective strategy for transdermal drug delivery. Many endeavors have been devoted to developing smart microneedles that can respond to and interact with pathophysiological environments. Here, novel bioinspired adaptable indwelling microneedles with therapeutic exosome encapsulation are presented for diabetic wound healing by a combined fabrication strategy of template replication and 3D transfer printing. Such microneedles are composed of mesenchymal stem cell (MSC)-exosomes-encapsulated adjustable poly(vinyl alcohol) (PVA) hydrogel needle tips and detachable 3M medical tape supporting substrate. As the mechanical strength of the PVA hydrogel is ionically responsive due to Hofmeister…

Citation impact

211
total citations
FWCI
22.13
Percentile
100%
References
46
Citations per year

Authors

5

Topics & keywords

Topics
Keywords
  • Materials science
  • Nanotechnology
  • Biomedical engineering
  • Medicine
UN Sustainable Development Goals
  • Good health and well-being
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