STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes

Stimulator of interferon genes (STING) is essential for the type I interferon response against a variety of DNA pathogens. Upon emergence of cytosolic DNA, STING translocates from the endoplasmic reticulum to the Golgi where STING activates the downstream kinase TBK1, then to lysosome through recycling endosomes (REs) for its degradation. Although the molecular machinery of STING activation is extensively studied and defined, the one underlying STING degradation and inactivation has not yet been fully elucidated. Here we show that STING is degraded by the endosomal sorting complexes required for transport (ESCRT)-driven microautophagy. Airyscan super-resolution microscopy and correlative light/electron…

• CS
  Cell Science Research Foundation
• SF
  Sumitomo Foundation
• NF
  Nakatomi Foundation
• JA
  Japan Agency for Medical Research and Development

  Awards: CREST, 17939604, JP20H03415
• PT
  Princess Takamatsu Cancer Research Fund
• JS
  Japan Society for the Promotion of Science

  Awards: 19J21426, JP17H06164, JP17H06418, JP20H03202, JP20H05307, JP19H00974, CREST, JP17K15445, 17939604, 19J23315
• CR
  Core Research for Evolutional Science and Technology

  Awards: JPMJCR21E4, 17939604