Tissue-specific macrophages: how they develop and choreograph tissue biology

Macrophages are innate immune cells that form a 3D network in all our tissues, where they phagocytose dying cells and cell debris, immune complexes, bacteria and other waste products. Simultaneously, they produce growth factors and signalling molecules — such activities not only promote host protection in response to invading microorganisms but are also crucial for organ development and homeostasis. There is mounting evidence of macrophages orchestrating fundamental physiological processes, such as blood vessel formation, adipogenesis, metabolism and central and peripheral neuronal function. In parallel, novel methodologies have led to the characterization of tissue-specific macrophages, with distinct…

• EC
  European Commission

  Award: 851257
• DF
  Deutsche Forschungsgemeinschaft

  Awards: SFB1454, GRK1873, FOR2886, CRC1526, GRK1873/2, EXC 2151, 491676693, 390939984, TRR305-B02, 259373024, FOR2953, CRC1479, TRR305, TRR167, EXC-2189, TRR359, 44189134, SFB/TRR167, CRC 1181, 390873048, SCHL2116/1, FOR2953-P3
• FT
  Fritz Thyssen Stiftung
• NI
  National Institutes of Health

  Award: U19 AI142790