Versatility of bacterial outer membrane vesicles in regulating intestinal homeostasis
Shanghai Jiao Tong University · Renji Hospital · +2 more institutions
Abstract
Outer membrane vesicles (OMVs) play vital roles in bacterial communication both intraspecifically and interspecifically. However, extracellular mechanisms of gut microbiota–derived OMVs in the intestine remain poorly understood. Here, we report that OMVs released from Akkermansia muciniphila are able to (i) restore disturbed balance of the gut microbiota by selectively promoting the proliferation of beneficial bacteria through membrane fusion, (ii) elicit mucosal immunoglobulin A response by translocating into Peyer’s patches and subsequently activating B cells and dendritic cells, and (iii) maintain the integrity of the intestinal barrier by entering intestinal epithelial cells to stimulate the expressions of…
Citation impact
- FWCI
- 27.96
- Percentile
- 100%
- References
- 62
Authors
8- XWXinyue WangCorresponding
Shanghai Jiao Tong University, Renji Hospital, Shanghai Cancer Institute, State Key Laboratory of Oncogene and Related Genes
- SLSisi Lin
Shanghai Jiao Tong University, Renji Hospital, Shanghai Cancer Institute, State Key Laboratory of Oncogene and Related Genes
- LWLu Wang
Shanghai Jiao Tong University, Renji Hospital, Shanghai Cancer Institute, State Key Laboratory of Oncogene and Related Genes
- ZCZhenping Cao
Shanghai Jiao Tong University, Renji Hospital, Shanghai Cancer Institute, State Key Laboratory of Oncogene and Related Genes
- MZMengmeng Zhang
Shanghai Jiao Tong University, Renji Hospital, Shanghai Cancer Institute, State Key Laboratory of Oncogene and Related Genes
Topics & keywords
- Cell biology
- Akkermansia muciniphila
- Bacterial outer membrane
- Biology
- Microbiology
- Gut flora
- Immune system
- Intestinal mucosa
- Good health and well-being