Discovering highly potent antimicrobial peptides with deep generative model HydrAMP

Antimicrobial peptides emerge as compounds that can alleviate the global health hazard of antimicrobial resistance, prompting a need for novel computational approaches to peptide generation. Here, we propose HydrAMP, a conditional variational autoencoder that learns lower-dimensional, continuous representation of peptides and captures their antimicrobial properties. The model disentangles the learnt representation of a peptide from its antimicrobial conditions and leverages parameter-controlled creativity. HydrAMP is the first model that is directly optimized for diverse tasks, including unconstrained and analogue generation and outperforms other approaches in these tasks. An additional preselection procedure…

• N
  Nvidia
• UW
  Uniwersytet Warszawski
• IC
  Interdyscyplinarne Centrum Modelowania Matematycznego i Komputerowego UW