Pharmacogenomics: Driving Personalized Medicine
Hospital of the University of Pennsylvania · The Ohio State University · +3 more institutions
Abstract
Personalized medicine tailors therapies, disease prevention, and health maintenance to the individual, with pharmacogenomics serving as a key tool to improve outcomes and prevent adverse effects. Advances in genomics have transformed pharmacogenetics, traditionally focused on single gene-drug pairs, into pharmacogenomics, encompassing all "-omics" fields (e.g., proteomics, transcriptomics, metabolomics, and metagenomics). This review summarizes basic genomics principles relevant to translation into therapies, assessing pharmacogenomics' central role in converging diverse elements of personalized medicine. We discuss genetic variations in pharmacogenes (drug-metabolizing enzymes, drug transporters, and…
Citation impact
- FWCI
- 45.43
- Percentile
- 100%
- References
- 273
Authors
4- WSWolfgang SadéeCorresponding
Hospital of the University of Pennsylvania, The Ohio State University, University of Florida, American Association of Colleges of Pharmacy, University of California, San Francisco
- DWDaqing Wang
University of California, San Francisco, American Association of Colleges of Pharmacy, The Ohio State University, Hospital of the University of Pennsylvania, University of Florida
- KEKatherine E. Hartmann
American Association of Colleges of Pharmacy, University of California, San Francisco, The Ohio State University, University of Florida, Hospital of the University of Pennsylvania
- AEAmanda E. Toland
American Association of Colleges of Pharmacy, Hospital of the University of Pennsylvania, University of Florida, The Ohio State University, University of California, San Francisco
Topics & keywords
- Pharmacogenomics
- Personalized medicine
- Precision medicine
- Medicine
- Traditional medicine
- Computational biology
- Bioinformatics
- Biology