Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes
University of California, San Francisco · UCSF Helen Diller Family Comprehensive Cancer Center · +4 more institutions
Abstract
T cells (Tex-int), consistent with activation and differentiation. LN responses coincided with increased circulating Tex-int. In metastatic LNs, these response hallmarks were impaired, with immunosuppressive cellular niches. Our results identify important roles for LNs in anti-tumor immune responses in humans.
Citation impact
- FWCI
- 91.36
- Percentile
- 100%
- References
- 98
Authors
23- MKMaha K. Rahim
University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center
- TLTrine Line Hauge Okholm
University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center
- KBKyle B. Jones
University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center
- EMElizabeth McCarthy
University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center
- CCCandace C. Liu
Stanford University
Topics & keywords
- Biology
- Lymph
- Immunotherapy
- Cancer
- Cancer immunotherapy
- CD8
- Cytotoxic T cell
- Cancer research
- Good health and well-being
Funding
- NSNational Science Foundation
- CRCancer Research Institute
- NINational Institutes of HealthAward: S10 OD018040
- GGenentech
- UOUniversity of California, San Francisco
- NINational Institute of Dental and Craniofacial ResearchAward: R01 DE032033
- HDHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco