Hydrocortisone in Severe Community-Acquired Pneumonia
Université de Tours · Inserm · +35 more institutions
Abstract
Whether the antiinflammatory and immunomodulatory effects of glucocorticoids may decrease mortality among patients with severe community-acquired pneumonia is unclear.
In this phase 3, multicenter, double-blind, randomized, controlled trial, we assigned adults who had been admitted to the intensive care unit (ICU) for severe community-acquired pneumonia to receive intravenous hydrocortisone (200 mg daily for either 4 or 7 days as determined by clinical improvement, followed by tapering for a total of 8 or 14 days) or to receive placebo. All the patients received standard therapy, including antibiotics and supportive care. The primary outcome was death at 28 days.
Citation impact
- FWCI
- 77.03
- Percentile
- 100%
- References
- 32
Authors
38- PDPierre‐François DequinCorresponding
Université de Tours, Inserm, Université de Lille, Centre Hospitalier Universitaire de Tours, Centre Hospitalier Universitaire de Liège, methodS in Patient-centered outcomes and HEalth ResEarch, Nantes Université
- FMFerhat Meziani
Université de Tours, Inserm, Université de Lille, Regenerative NanoMedicine, Centre Hospitalier Universitaire de Tours, Centre Hospitalier Universitaire de Liège, methodS in Patient-centered outcomes and HEalth ResEarch, Université de Strasbourg, Nantes Université
- JQJean‐Pierre Quenot
Université de Tours, Inserm, Université de Bourgogne, Université de Lille, Centre Hospitalier Universitaire de Tours, Centre Hospitalier Universitaire de Liège, Hôpitaux Universitaires de Strasbourg, methodS in Patient-centered outcomes and HEalth ResEarch, Nantes Université
- TKToufik Kamel
Université de Tours, Inserm, Université de Lille, Centre Hospitalier Universitaire de Tours, Centre Hospitalier Universitaire de Liège, methodS in Patient-centered outcomes and HEalth ResEarch, Nantes Université
- JRJean‐Damien Ricard
Université de Tours, Inserm, Université Paris Cité, Université de Lille, Centre Hospitalier Universitaire de Tours, Centre Hospitalier Universitaire de Liège, methodS in Patient-centered outcomes and HEalth ResEarch, Imation (United States), Nantes Université
Topics & keywords
- Medicine
- Placebo
- Confidence interval
- Intensive care unit
- Randomization
- Mechanical ventilation
- Pneumonia
- Randomized controlled trial
- Good health and well-being