To metabolomics and beyond: a technological portfolio to investigate cancer metabolism
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Abstract
Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support tumour initiation, progression, metastasis and resistance to therapies. These reprogrammed activities include a complete rewiring of the bioenergetic, biosynthetic and redox status to sustain the increased energetic demand of the cells. Over the last decades, the cancer metabolism field has seen an explosion of new biochemical technologies giving more tools than ever before to navigate this complexity. Within a cell or a tissue, the metabolites constitute the direct signature of the molecular phenotype and thus their profiling has concrete clinical applications in oncology. Metabolomics and fluxomics, are key…
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231
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Authors
7Topics & keywords
Topics
Keywords
- Metabolomics
- Computational biology
- Reprogramming
- Biology
- Bioinformatics
- Cancer
- Identification (biology)
- Cellular metabolism
UN Sustainable Development Goals
- Industry, innovation and infrastructure
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