Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders

Hatoum, Alexander S.; Colbert, Sarah M. C.; Johnson, Emma C.; Huggett, Spencer B.; Deak, Joseph D.; Pathak, Gita A.; Jennings, Mariela; Paul, Sarah E.; Karcher, Nicole R.; Hansen, Isabella; Baranger, David A. A.; Edwards, Alexis C.; Grotzinger, Andrew D.; Adkins, Daniel E.; Adkins, Amy; Alanne-Kinnunen, Mervi; Alexander, Jeffry; Alıev, Fazil; Bacanu, Silviu‐Alin; Batzler, Anthony; Biernacka, Joanna M.; Bierut, Laura J.; Bigdeli, Tim B.; Благонравова, А. С.; Boardman, Jason D.; Boden, Joseph M.; Boomsma, Dorret I.; Brown, Sandra A.; Bucholz, Kathleen K.; Chen, Danfeng; Chen, Li‐Shiun; Choi, Doo‐Sup; Chou, S. Patricia; Cichon, Sven; Copeland, William; Corley, Robin P.; Degenhardt, Franziska; Forti, Marta Di; Diazgranados, Nancy; Dick, Danielle M.; Domingue, Benjamin W.; Eriksson, Johan G.; Farrer, Lindsay A.; Foo, Jerome C.; Foroud, Tatiana; Fox, Louis; Frank, Josef; Frye, Mark A.; Gäebel, Wolfgang; Gainetdinov, Raul R.; Giegling, Ina; Gillespie, Nathan A.; Goate, Alison; Goldman, David; Gordon, Scott D.; Hack, Laura M.; Hancock, Dana B.; Harris, Kathleen Mullan; Hartmann, Annette M.; Heath, Andrew C.; Heilmann‐Heimbach, Stefanie; Herms, Stefan; Hesselbrock, Victor; Hewitt, John K.; Hickie, Ian B.; Hodgkinson, Colin A.; Hoffmann, Per; Hopfer, Christian J.; Horwood, L. John; Hottenga, Jouke Jan; Howrigan, Daniel P.; Iacono, William G.; Ising, Marcus; Johnson, Eric O.; Kaprio, Jaakko; Karpyak, Victor M.; Kendler, Kenneth S.; Kennedy, Martin A.; Keyes, Margaret A.; Кибитов, А.О.; Kiefer, Falk; Konte, Bettina; Kramer, John R.; Krauter, Kenneth; Krupitsky, Evgeny; Kuperman, Samuel; Lahti, Jari; Lahti‐Pulkkinen, Marius; Lai, Dongbing; Levchenko, Аnastasia; Ligthart, Lannie; Lind, Penelope A.; Lucae, Susanne; Lynskey, Michael T.; Madden, Pamela A. F.; Maes, Hermine H.; Magnusson, Patrik K. E.; Maher, Brion S.; Mann, Karl; Männistö, Satu; Martin, Nicholas G.; Mbarek, Hamdi; McGue, Matt; McQueen, Matthew B.; Medland, Sarah E.; Meyers, Jacquelyn L.; Montgomery, Grant W.; Müller‐Myhsok, Bertram; Neale, Benjamin M.; Nelson, Elliot C.; Nöthen, Markus M.; Nürnberger, John I.; Palotie, Aarno; Palviainen, Teemu; Pearson, John F.; Pedersen, Nancy L.; Penninx, Brenda W.J.H.; Peterson, Roseann E.; Porjesz, Bernice; Preuss, Ulrich W.; Quattrone, Diego; Räikkönen, Katri; Reynolds, Maureen; Rice, John P.; Ridinger, Monika; Rietschel, Marcella; Riley, Brien P.; Ripatti, Samuli; Rose, Richard J.; Rujescu, Dan; Rybakova, Ksenia V.; Ryu, Euijung; Saccone, Nancy L.; Salvatore, Jessica E.; Scherbaum, Norbert; Schuckit, Marc A.; Schwandt, Melanie L.; Shen, Pei‐Hong; Sherva, Richard; Silberg, Judy L.; Stallings, Michael C.; Stein, Dan J.; Streit, Fabian; Strohmaier, Jana; Tarter, Ralph E.; Thomas, Nathaniel; Vanyukov, Michael M.; Vrieze, Scott; Wall, Tamara L.; Walters, Raymond K.; Webb, Bradley T.; Wedow, Robbee; Wendt, Frank R.; Wetherill, Leah; Whitfield, John B.; Witt, Stephanie H.; Wodarz, Norbert; Wright, Margaret J.; Hartz, Sarah M.; Zellers, Stephanie; Zhang, Haitao; Zhao, Hongyu; Zhou, Hang; Zill, Peter; Zillich, Lea; Tucker–Drob, Elliot M.; Kranzler, Henry R.; Davis, Lea K.; Sanchez‐Roige, Sandra; Polimanti, Renato; Gelernter, Joel; Edenberg, Howard J.; Bogdan, Ryan; Agrawal, Arpana

doi:10.1038/s44220-023-00034-y

articleNature Mental HealthMar 22, 2023BRONZE OA

Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders

ASAlexander S. Hatoum SMSarah M. C. Colbert ECEmma C. Johnson SBSpencer B. Huggett JDJoseph D. Deak

Washington University in St. Louis · Emory University · +81 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

No abstract available for this paper.

Citation impact

225

total citations

FWCI: 64.61
Percentile: 100%
References: 74

Citations per year

Authors

174

AS
Alexander S. HatoumCorresponding
Washington University in St. Louis
SM
Sarah M. C. Colbert
Washington University in St. Louis
EC
Emma C. Johnson
Washington University in St. Louis
SB
Spencer B. Huggett
Emory University
JD
Joseph D. Deak
Yale University, VA Connecticut Healthcare System

Topics & keywords

Topics

Genetic Associations and Epidemiology100%
Substance Abuse Treatment and Outcomes100%
Alcohol Consumption and Health Effects99%

Keywords

Genome-wide association study
Cannabis
Substance use
Addiction
Multivariate analysis
Multivariate statistics
Meta-analysis
Genetic association

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.

Funding

MR
Medical Research Council
Award: MR/W030608/1
NI
National Institute on Alcohol Abuse and Alcoholism
Awards: AA029934, AA030083, AA027522, AA028259
NI
National Institute of Mental Health
Awards: MH120219, MH014276, MH121792
NI
National Institute on Drug Abuse
Awards: DA54869, DA54750, DA047527, DA007261, DA32573, DA51759, DA055367, DA54394