A mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut

Objective Ample evidence exists for the role of abnormal gut microbiota composition and increased gut permeability (‘leaky gut’) in chronic inflammation that commonly co-occurs in the gut in both obesity and diabetes, yet the detailed mechanisms involved in this process have remained elusive. Design In this study, we substantiate the causal role of the gut microbiota by use of faecal conditioned media along with faecal microbiota transplantation. Using untargeted and comprehensive approaches, we discovered the mechanism by which the obese microbiota instigates gut permeability, inflammation and abnormalities in glucose metabolism. Results We demonstrated that the reduced capacity of the microbiota from both…

• UD
  U.S. Department of Defense

  Awards: W81XWH-19-1-0236, W81XWH
• UO
  University of South Florida
• NI
  National Institutes of Health

  Awards: R56AG069676, R56AG064075, RF1AG071762, R21AG072379, W81XWH, U01AG076928
• WF
  Wake Forest School of Medicine