Dendritic cell subsets in cancer immunity and tumor antigen sensing
Humanitas University · IRCCS Humanitas Research Hospital · +4 more institutions
Abstract
Dendritic cells (DCs) exhibit a specialized antigen-presenting function and play crucial roles in both innate and adaptive immune responses. Due to their ability to cross-present tumor cell-associated antigens to naïve T cells, DCs are instrumental in the generation of specific T-cell-mediated antitumor effector responses in the control of tumor growth and tumor cell dissemination. Within an immunosuppressive tumor microenvironment, DC antitumor functions can, however, be severely impaired. In this review, we focus on the mechanisms of DC capture and activation by tumor cell antigens and the role of the tumor microenvironment in shaping DC functions, taking advantage of recent studies showing the phenotype…
Citation impact
- FWCI
- 88.50
- Percentile
- 100%
- References
- 266
Authors
7- ADAnnalisa Del PreteCorresponding
Humanitas University, IRCCS Humanitas Research Hospital, University of Brescia
- VSValentina Salvi
University of Brescia
- ASAlessandra Soriani
Istituto Pasteur, Sapienza University of Rome
- MLMattia Laffranchi
Istituto Pasteur, Sapienza University of Rome
- FSFrancesca Sozio
Istituto Pasteur, Sapienza University of Rome
Topics & keywords
- Tumor microenvironment
- Antigen
- Immune system
- Priming (agriculture)
- Dendritic cell
- Biology
- Acquired immune system
- Effector
- Good health and well-being