A Review of Gut Microbiota‐Derived Metabolites in Tumor Progression and Cancer Therapy

Gut microbiota-derived metabolites are key hubs connecting the gut microbiome and cancer progression, primarily by remodeling the tumor microenvironment and regulating key signaling pathways in cancer cells and multiple immune cells. The use of microbial metabolites in radiotherapy and chemotherapy mitigates the severe side effects from treatment and improves the efficacy of treatment. Immunotherapy combined with microbial metabolites effectively activates the immune system to kill tumors and overcomes drug resistance. Consequently, various novel strategies have been developed to modulate microbial metabolites. Manipulation of genes involved in microbial metabolism using synthetic biology approaches directly…

• GO
  Government of Jiangsu Province
• NS
  Natural Science Foundation of Jiangsu Province

  Awards: BK20180043, 19KJA550003
• PA
  Priority Academic Program Development of Jiangsu Higher Education Institutions
• NS
  National Science Fund for Distinguished Young Scholars

  Awards: 31925013, 32125016