Iron-Catalyzed C(Sp 3 )–H Borylation, Thiolation, and Sulfinylation Enabled by Photoinduced Ligand-to-Metal Charge Transfer

Catalytic C(sp3)–H functionalization has provided enormous opportunities to construct organic molecules, facilitating the derivatization of complex pharmaceutical compounds. Within this framework, direct hydrogen atom transfer (HAT) photocatalysis becomes an appealing approach to this goal. However, the viable substrates utilized in these protocols are limited, and the site selectivity shows preference to activated and thermodynamically favored C(sp3)–H bonds. Herein, we describe the development of undirected iron-catalyzed C(sp3)–H borylation, thiolation, and sulfinylation reactions enabled by the photoinduced ligand-to-metal charge transfer (LMCT) process. These reactions exhibit remarkably broad substrate…

• HN
  Henan Normal University
• NN
  National Natural Science Foundation of China

  Award: 22101066
• NS
  Natural Science Foundation of Guangdong Province

  Award: 2022A1515010863
• SK
  State Key Laboratory of Urban Water Resource and Environment

  Award: 2022TS23
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Award: 2021A1515220069