Modular-designed engineered bacteria for precision tumor immunotherapy via spatiotemporal manipulation by magnetic field
Chinese Academy of Sciences · Peking University · +6 more institutions
Abstract
Abstract Micro-nano biorobots based on bacteria have demonstrated great potential for tumor diagnosis and treatment. The bacterial gene expression and drug release should be spatiotemporally controlled to avoid drug release in healthy tissues and undesired toxicity. Herein, we describe an alternating magnetic field-manipulated tumor-homing bacteria developed by genetically modifying engineered Escherichia coli with Fe 3 O 4 @lipid nanocomposites. After accumulating in orthotopic colon tumors in female mice, the paramagnetic Fe 3 O 4 nanoparticles enable the engineered bacteria to receive and convert magnetic signals into heat, thereby initiating expression of lysis proteins under the control of a…
Citation impact
- FWCI
- 54.07
- Percentile
- 100%
- References
- 60
Authors
15- XMXiaotu MaCorresponding
Chinese Academy of Sciences, Peking University, Institute of Genetics and Developmental Biology, National Center for Nanoscience and Technology, Peking University Third Hospital
- XLXiaolong Liang
Peking University, Peking University Third Hospital
- YLYao Li
Xiamen University, National Center for Nanoscience and Technology
- QFQingqing Feng
National Center for Nanoscience and Technology
- KCKeman Cheng
National Center for Nanoscience and Technology
Topics & keywords
- Bacteria
- Homing (biology)
- Cancer research
- Biology
- Materials science
- Good health and well-being