A stretchable wireless wearable bioelectronic system for multiplexed monitoring and combination treatment of infected chronic wounds

Chronic nonhealing wounds are one of the major and rapidly growing clinical complications all over the world. Current therapies frequently require emergent surgical interventions, while abuse and misapplication of therapeutic drugs often lead to an increased morbidity and mortality rate. Here, we introduce a wearable bioelectronic system that wirelessly and continuously monitors the physiological conditions of the wound bed via a custom-developed multiplexed multimodal electrochemical biosensor array and performs noninvasive combination therapy through controlled anti-inflammatory antimicrobial treatment and electrically stimulated tissue regeneration. The wearable patch is fully biocompatible, mechanically…

• NS
  National Science Foundation

  Award: 2145802
• CI
  California Institute of Technology
• HM
  Heritage Medical Research Institute
• NI
  National Institutes of Health

  Awards: R01HL155815, R21DK13266
• BI
  Beckman Institute, California Institute of Technology
• OO
  Office of Naval Research

  Awards: N00014-21-1-2845, N00014-21-1-2483, N00014