Pathogenesis of allergic diseases and implications for therapeutic interventions

Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD), food allergy (FA), and eczema are systemic diseases caused by an impaired immune system. Accompanied by high recurrence rates, the steadily rising incidence rates of these diseases are attracting increasing attention. The pathogenesis of allergic diseases is complex and involves many factors, including maternal-fetal environment, living environment, genetics, epigenetics, and the body's immune status. The pathogenesis of allergic diseases exhibits a marked heterogeneity, with phenotype and endotype defining visible features and associated molecular mechanisms, respectively. With the rapid development of immunology,…

• NN
  National Natural Science Foundation of China

  Awards: 2020YFC2003100, 81973715
• CA
  Chinese Academy of Sciences

  Award: 202001
• SO
  School of Medicine, Duke University
• BI
  Beijing Institute of Genomics, Chinese Academy of Sciences