Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

Wnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either through β-catenin in the canonical pathway or through a series of other proteins in the noncanonical pathway. Many of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body, establishing the complex interplay between Wnt signaling and other signaling pathways. This crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ…

• UO
  University of Chicago

  Award: P30CA014599
• AS
  American Shoulder and Elbow Surgeons
• NN
  National Natural Science Foundation of China

  Award: 82102696
• CM
  Chongqing Municipal Education Commission

  Award: KJQN201900410
• CM
  Chongqing Municipal Human Resources and Social Security Bureau

  Award: T32 GM007281
• NI
  National Institutes of Health

  Awards: CA226303, T32 GM007281, DE030480, 5UL1TR002389, P30CA014599, GM007281
• NC
  National Center for Advancing Translational Sciences

  Award: 5UL1TR002389