articleAdvanced Functional MaterialsMar 25, 2023BRONZE OA

Double Cross‐Linked Biomimetic Hyaluronic Acid‐Based Hydrogels with Thermo‐Stimulated Self‐Contraction and Tissue Adhesiveness for Accelerating Post‐Wound Closure and Wound Healing

YZYaodong ZhaoBYBingcheng YiJHJilin HuDZDongjie ZhangGLGuotai Li

Qingdao University · Affiliated Hospital of Qingdao University · +1 more institution

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Abstract

Abstract When skin trauma occurs, rapid achievement of the post‐wound closure is required to prevent microbial invasion, inhibit scar formation and promote wound healing. To develop a wound dressing for accelerating post‐wound‐closure and wound healing, a thermo‐responsive and tissue‐adhesive hydrogel with interpenetrating polymer networks (IPN) is fabricated based on N ‐dimethylbisacrylamide (NIPAM) and glutaraldehyde (GTA) cross‐linked hyaluronic acid (HA). Results not only confirm the thermo‐stimulated self‐contraction and tissue adhesiveness of the HA‐based IPN (PNI‐HA), which effectively aids wound closure via mechanical stretch, but also verify the hemocompatibility and cytocompatibility of PNI‐HA that…

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178
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23.27
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100%
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73
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Authors

7

Topics & keywords

Topics
Keywords
  • Wound healing
  • Hyaluronic acid
  • Self-healing hydrogels
  • Materials science
  • Wound closure
  • Sealant
  • Biomedical engineering
  • Adhesive
UN Sustainable Development Goals
  • Good health and well-being
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