reviewCellsMar 25, 2023GOLD OA

Microglia Mediated Neuroinflammation in Parkinson’s Disease

SISevim IşıkKBKiyak Bercem YemanRARümeysa AkbayırRŞRama Şeyhali-AbutayehTYTahire Yurdakul

Üsküdar University · Sağlık Bilimleri Üniversitesi

PubMed
Indexed incrossrefdoajpubmed

Abstract

Parkinson's Disease (PD) is the second most common neurodegenerative disorder seen, especially in the elderly. Tremor, shaking, movement problems, and difficulty with balance and coordination are among the hallmarks, and dopaminergic neuronal loss in substantia nigra pars compacta of the brain and aggregation of intracellular protein α-synuclein are the pathological characterizations. Neuroinflammation has emerged as an involving mechanism at the initiation and development of PD. It is a complex network of interactions comprising immune and non-immune cells in addition to mediators of the immune response. Microglia, the resident macrophages in the CNS, take on the leading role in regulating neuroinflammation…

Citation impact

316
total citations
FWCI
36.61
Percentile
100%
References
240
Citations per year

Authors

5

Topics & keywords

Topics
Keywords
  • Neuroinflammation
  • Microglia
  • Neuroscience
  • Pars compacta
  • Substantia nigra
  • Parkinson's disease
  • Inflammation
  • Immune system
UN Sustainable Development Goals
  • Good health and well-being
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