Short chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections
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Abstract
The human intestinal microbiome substantially affects human health and resistance to infections in its dynamic composition and varying release of microbial-derived metabolites. Short-chain fatty acids (SCFA) produced by commensal bacteria through fermentation of indigestible fibres are considered key regulators in orchestrating the host immune response to microbial colonization by regulating phagocytosis, chemokine and central signalling pathways of cell growth and apoptosis, thereby shaping the composition and functionality of the intestinal epithelial barrier. Although research of the last decades provided valuable insight into the pleiotropic functions of SCFAs and their capability to maintain human health,…
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6Topics & keywords
Topics
Keywords
- Biology
- Immune system
- Microbiome
- Chemokine
- Cell biology
- Inflammation
- Gut flora
- Immunology
UN Sustainable Development Goals
- Good health and well-being
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