articleDrug Resistance UpdatesMar 28, 2023HYBRID OA

Cancer-associated fibroblasts suppress ferroptosis and induce gemcitabine resistance in pancreatic cancer cells by secreting exosome-derived ACSL4-targeting miRNAs

RQRan QiYBYixuan BaiKLKun LiNLNanbin LiuYXYan Xu

Tongji University · Tongji Hospital · +4 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Pancreatic cancer continues to be one of the world's most lethal cancers. Chemotherapy resistance in patients with advanced pancreatic cancer often accompany with dismal prognosis, highlighting the need to investigate mechanisms of drug resistance and develop therapies to overcome chemoresistance. This research was filed with the Chinese Clinical Trial Registry (ChiCTR2200061320). In order to isolate primary normal fibroblasts (NFs) and cancer-associated fibroblasts (CAFs) samples of pancreatic ductal adenocarcinoma (PDAC) and paracancerous pancreatic tissue from individuals diagnosed with PDAC were obtained. The exosomes were obtained using ultracentrifugation, and their characteristics were determined by…

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271
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Authors

13

Topics & keywords

Topics
Keywords
  • Pancreatic cancer
  • Gemcitabine
  • Microvesicles
  • Cancer research
  • Cancer
  • Exosome
  • Cancer cell
  • microRNA
UN Sustainable Development Goals
  • Good health and well-being
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