Helicobacter pylori , Homologous-Recombination Genes, and Gastric Cancer
Okayama University · Center for Cancer Research · +10 more institutions
Abstract
Helicobacter pylori infection is a well-known risk factor for gastric cancer. However, the contribution of germline pathogenic variants in cancer-predisposing genes and their effect, when combined with H. pylori infection, on the risk of gastric cancer has not been widely evaluated. We evaluated the association between germline pathogenic variants in 27 cancer-predisposing genes and the risk of gastric cancer in a sample of 10,426 patients with gastric cancer and 38,153 controls from BioBank Japan. We also assessed the combined effect of pathogenic variants and H. pylori infection status on the risk of gastric cancer and calculated the cumulative risk in 1433 patients with gastric cancer and 5997 controls from…
Citation impact
- FWCI
- 69.87
- Percentile
- 100%
- References
- 31
Authors
28- YUYoshiaki UsuiCorresponding
Okayama University, Center for Cancer Research, RIKEN Center for Integrative Medical Sciences
- YTYukari Taniyama
Center for Cancer Research, RIKEN Center for Integrative Medical Sciences
- MEMikiko Endo
Center for Cancer Research
- YNYuriko N. Koyanagi
Center for Cancer Research, RIKEN Center for Integrative Medical Sciences
- YKYumiko Kasugai
Aichi Cancer Center, Center for Cancer Research
Topics & keywords
- PALB2
- Cancer
- MLH1
- Helicobacter pylori
- Internal medicine
- MSH2
- Medicine
- Gastroenterology
- Good health and well-being