Spatial multiomics map of trophoblast development in early pregnancy

Abstract The relationship between the human placenta—the extraembryonic organ made by the fetus, and the decidua—the mucosal layer of the uterus, is essential to nurture and protect the fetus during pregnancy. Extravillous trophoblast cells (EVTs) derived from placental villi infiltrate the decidua, transforming the maternal arteries into high-conductance vessels 1 . Defects in trophoblast invasion and arterial transformation established during early pregnancy underlie common pregnancy disorders such as pre-eclampsia 2 . Here we have generated a spatially resolved multiomics single-cell atlas of the entire human maternal–fetal interface including the myometrium, which enables us to resolve the full trajectory…

• WT
  Wellcome Trust

  Awards: 211276/Z/18/Z, 220540/Z/20/A, WT206194, 220540, 211276, 200841, 200841/Z/16/Z
• RS
  Royal Society

  Awards: DH160216, RGF\R1\180028
• UO
  University of Cambridge
• EC
  European Commission

  Awards: 220540, 853546
• MR
  Medical Research Council

  Award: MR/S036350/1