Apoptosis-Amplified Assembly of Porphyrin Nanofiber Enhances Photodynamic Therapy of Oral Tumor
State Key Laboratory of Digital Medical Engineering · Southeast University · +1 more institution
Abstract
Oral squamous cell carcinoma (OSCC) is the most common oral cancer, having high recurrence and metastasis features. In addition to surgery, photodynamic therapy (PDT) is considered as another effective approach for OSCC treatment. The water solubility of currently available PDT photosensitizers (PSs) is poor, lowering their singlet oxygen (1O2) yield and consequent PDT efficiency. Strategies of PS assembly have been reported to increase 1O2 yield, but it is still possible to further enhance PDT efficiency. In this work, we utilized apoptosis to amplify the assembly of porphyrin nanofibers for enhanced PDT of OSCC. A water-soluble porphyrin derivative, Ac-Asp-Glu-Val-Asp-Asp-TPP (Ac-DEVDD-TPP), was designed for…
Citation impact
- FWCI
- 49.17
- Percentile
- 100%
- References
- 66
Authors
10- XLXiaoyang Liu
State Key Laboratory of Digital Medical Engineering, Southeast University
- WZWenjun Zhan
State Key Laboratory of Digital Medical Engineering, Southeast University
- GGGe Gao
State Key Laboratory of Digital Medical Engineering, Southeast University
- QJQiaochu Jiang
State Key Laboratory of Digital Medical Engineering, Southeast University
- XZXinping Zhang
State Key Laboratory of Digital Medical Engineering, Southeast University
Topics & keywords
- Porphyrin
- Photodynamic therapy
- Chemistry
- Apoptosis
- In vivo
- Photosensitizer
- Cancer research
- Singlet oxygen
- Clean water and sanitation