Integration of TADF Photosensitizer as “Electron Pump” and BSA as “Electron Reservoir” for Boosting Type I Photodynamic Therapy

Type I photosensitization provides an effective solution to the problem of unsatisfactory photodynamic therapeutic (PDT) effects caused by the tumor hypoxia. The challenge in the development of Type I mode is to boost the photosensitizer’s own electron transfer capacity. Herein, we found that the use of bovine serum albumin (BSA) to encapsulate a thermally activated delayed fluorescence (TADF) photosensitizer PS can significantly promote the Type I PDT process to generate a mass of superoxide anions (O2•–). This Type I photosensitization opened a new strategy by employing BSA as “electron reservoir” and TADF photosensitizer as “electron pump”. We integrated these roles of BSA and PS in one system by preparing…

• SU
  Shandong University
• NN
  National Natural Science Foundation of China

  Award: 21877011
• CU
  Central University Basic Research Fund of China

  Award: DUT22YG115