Tumor microenvironment signaling and therapeutics in cancer progression
Northwestern University · Robert H. Lurie Comprehensive Cancer Center of Northwestern University · +10 more institutions
Abstract
Tumor development and metastasis are facilitated by the complex interactions between cancer cells and their microenvironment, which comprises stromal cells and extracellular matrix (ECM) components, among other factors. Stromal cells can adopt new phenotypes to promote tumor cell invasion. A deep understanding of the signaling pathways involved in cell-to-cell and cell-to-ECM interactions is needed to design effective intervention strategies that might interrupt these interactions. In this review, we describe the tumor microenvironment (TME) components and associated therapeutics. We discuss the clinical advances in the prevalent and newly discovered signaling pathways in the TME, the immune checkpoints and…
Citation impact
- FWCI
- 58.59
- Percentile
- 100%
- References
- 443
Authors
8- AGAnshika GoenkaCorresponding
Northwestern University, Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- FKFatima Khan
Northwestern University, Neurological Surgery
- BVBhupender Verma
Massachusetts Eye and Ear Infirmary, Harvard University, Smith-Kettlewell Eye Research Institute
- PSPriyanka Sinha
Harvard University, Massachusetts General Hospital, MaineGeneral Medical Center
- CDCrismita Dmello
Northwestern University, Neurological Surgery
Topics & keywords
- Tumor microenvironment
- Cell biology
- Cancer research
- Biology
- CXCL14
- Signal transduction
- CCL21
- Chemokine receptor
- Good health and well-being