Targeting glutamine metabolism as a therapeutic strategy for cancer

Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as well as a source of nitrogen for amino acid and nucleotide synthesis. To date, many studies have explored the role of glutamine metabolism in cancer, thereby providing a scientific rationale for targeting glutamine metabolism for cancer treatment. In this review, we summarize the mechanism(s) involved at each step of glutamine metabolism, from glutamine transporters to redox homeostasis, and highlight areas that can be exploited for clinical cancer treatment. Furthermore, we discuss the mechanisms underlying cancer cell…

• NR
  National Research Foundation

  Award: 2020R1A5A2017323
• NR
  National Research Foundation of Korea

  Awards: NRF-2022R1A2C1008591, NRF-2021R1C1C2003405, NRF-2020R1A5A2017323, 2022R1A2C1008591, NRF-2022R1A2C100859111, 2021R1A2C3005603, 2020R1A5A2017323, 2021R1C1C2003405, NRF-2021R1A2C3005603
• MO
  Ministry of Science and ICT, South Korea

  Awards: NRF-2021R1A2C3005603, 2020R1A5A2017323, NRF-2022R1A2C1008591, NRF-2021R1C1C2003405