Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice

Parabacteroides distasonis (P. distasonis) plays an important role in human health, including diabetes, colorectal cancer and inflammatory bowel disease. Here, we show that P. distasonis is decreased in patients with hepatic fibrosis, and that administration of P. distasonis to male mice improves thioacetamide (TAA)- and methionine and choline-deficient (MCD) diet-induced hepatic fibrosis. Administration of P. distasonis also leads to increased bile salt hydrolase (BSH) activity, inhibition of intestinal farnesoid X receptor (FXR) signaling and decreased taurochenodeoxycholic acid (TCDCA) levels in liver. TCDCA produces toxicity in mouse primary hepatic cells (HSCs) and induces mitochondrial permeability…

• NN
  National Natural Science Foundation of China
• CP
  China Postdoctoral Science Foundation
• SU
  Sichuan University

  Award: 2021HXBH041
• NI
  National Institutes of Health
• NK
  National Key Research and Development Program of China

  Award: 2021YFF0702003
• FR
  Fundamental Research Funds for the Central Universities

  Award: 2022SCU12054
• WC
  West China Hospital, Sichuan University

  Award: 1.3.5
• NC
  National Cancer Institute