Macrophage function in adipose tissue homeostasis and metabolic inflammation

Obesity-related metabolic organ inflammation contributes to cardiometabolic disorders. In obese individuals, changes in lipid fluxes and storage elicit immune responses in the adipose tissue (AT), including expansion of immune cell populations and qualitative changes in the function of these cells. Although traditional models of metabolic inflammation posit that these immune responses disturb metabolic organ function, studies now suggest that immune cells, especially AT macrophages (ATMs), also have important adaptive functions in lipid homeostasis in states in which the metabolic function of adipocytes is taxed. Adverse consequences of AT metabolic inflammation might result from failure to maintain local…

• BI
  Boehringer Ingelheim
• DF
  Deutsche Forschungsgemeinschaft

  Awards: SFB-TRR 205, SFB-TRR 332, B4, AL1686/6-1