Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression
Shanghai University · Second Military Medical University · +4 more institutions
Abstract
Abnormal subchondral bone remodeling featured by overactivated osteoclastogenesis leads to articular cartilage degeneration and osteoarthritis (OA) progression, but the mechanism is unclear. We used lymphocyte cytosolic protein 1 ( Lcp1 ) knockout mice to suppress subchondral osteoclasts in a mice OA model with anterior cruciate ligament transection (ACLT), and Lcp1 −/− mice showed decreased bone remodeling in subchondral bone and retarded cartilage degeneration. For mechanisms, the activated osteoclasts in subchondral bone induced type-H vessels and elevated oxygen concentration, which ubiquitylated hypoxia-inducible factor 1 alpha subunit (HIF-1α) in chondrocytes and led to cartilage degeneration. Lcp1…
Citation impact
- FWCI
- 41.07
- Percentile
- 100%
- References
- 60
Authors
21- HZHao ZhangCorresponding
Shanghai University, Second Military Medical University, Shanghai Jiao Tong University, XinHua Hospital, Changhai Hospital
- LWLipeng WangCorresponding
Shanghai University
- JCJin CuiCorresponding
Shanghai University, Second Military Medical University, Changhai Hospital
- SWSicheng WangCorresponding
Shanghai University, Zhongshan Hospital
- YHYafei Han
Shanghai University
Topics & keywords
- Osteoarthritis
- Cartilage
- Knockout mouse
- Hypoxia (environmental)
- Gene knockdown
- Angiogenesis
- Medicine
- Degeneration (medical)