The KMT2A recombinome of acute leukemias in 2023
Goethe University Frankfurt · Instituto Nacional de Câncer - INCA · +55 more institutions
Abstract
Chromosomal rearrangements of the human KMT2A/MLL gene are associated with de novo as well as therapy-induced infant, pediatric, and adult acute leukemias. Here, we present the data obtained from 3401 acute leukemia patients that have been analyzed between 2003 and 2022. Genomic breakpoints within the KMT2A gene and the involved translocation partner genes (TPGs) and KMT2A-partial tandem duplications (PTDs) were determined. Including the published data from the literature, a total of 107 in-frame KMT2A gene fusions have been identified so far. Further 16 rearrangements were out-of-frame fusions, 18 patients had no partner gene fused to 5'-KMT2A, two patients had a 5'-KMT2A deletion, and one ETV6::RUNX1 patient…
Citation impact
- FWCI
- 57.23
- Percentile
- 100%
- References
- 76
Authors
68- CMClaus MeyerCorresponding
Goethe University Frankfurt
- PLPatrizia Larghero
Goethe University Frankfurt
- BABruno A. Lopes
Goethe University Frankfurt, Instituto Nacional de Câncer - INCA
- TBThomas Burmeister
Humboldt-Universität zu Berlin, Freie Universität Berlin, Charité - Universitätsmedizin Berlin
- DGDaniela Gröger
Humboldt-Universität zu Berlin, Freie Universität Berlin, Charité - Universitätsmedizin Berlin
Topics & keywords
- Breakpoint
- Chromosomal translocation
- Leukemia
- Acute leukemia
- Gene
- Gene rearrangement
- Cancer research
- Biology
- Good health and well-being