Mitochondria in health, disease, and aging
NewYork–Presbyterian Hospital · Cornell University · +3 more institutions
Abstract
Mitochondria are well known as organelles responsible for the maintenance of cellular bioenergetics through the production of ATP. Although oxidative phosphorylation may be their most important function, mitochondria are also integral for the synthesis of metabolic precursors, calcium regulation, the production of reactive oxygen species, immune signaling, and apoptosis. Considering the breadth of their responsibilities, mitochondria are fundamental for cellular metabolism and homeostasis. Appreciating this significance, translational medicine has begun to investigate how mitochondrial dysfunction can represent a harbinger of disease. In this review, we provide a detailed overview of mitochondrial metabolism,…
Citation impact
- FWCI
- 79.97
- Percentile
- 100%
- References
- 766
Authors
5- JSJohn S. Harrington
NewYork–Presbyterian Hospital, Cornell University, New York Hospital Queens, Presbyterian Hospital, Weill Cornell Medicine
- SWStefan W. Ryter
- MPMaria Plataki
NewYork–Presbyterian Hospital, Cornell University, New York Hospital Queens, Presbyterian Hospital, Weill Cornell Medicine
- DRDavid R. Price
NewYork–Presbyterian Hospital, Cornell University, New York Hospital Queens, Presbyterian Hospital, Weill Cornell Medicine
- AMAugustine M.K. ChoiCorresponding
NewYork–Presbyterian Hospital, Cornell University, New York Hospital Queens, Presbyterian Hospital, Weill Cornell Medicine
Topics & keywords
- Mitochondrion
- Bioenergetics
- Autophagy
- Cell biology
- Biology
- Oxidative phosphorylation
- Organelle
- Reactive oxygen species