Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials

Mesenchymal stromal/stem cells (MSCs) are widely utilized in cell therapy because of their robust immunomodulatory and regenerative properties. Their paracrine activity is one of the most important features that contribute to their efficacy. Recently, it has been demonstrated that the production of various factors via extracellular vesicles, especially exosomes, governs the principal efficacy of MSCs after infusion in experimental models. Compared to MSCs themselves, MSC-derived exosomes (MSC-Exos) have provided significant advantages by efficiently decreasing unfavorable adverse effects, such as infusion-related toxicities. MSC-Exos is becoming a promising cell-free therapeutic tool and an increasing number…

• UD
  U.S. Department of Veterans Affairs

  Award: I01BX004536
• UO
  University of South Carolina
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Awards: DK118529, DK120394, 1R01DK105183, DK120394, DK118529, 1R01DK105183, DK125464