Rational Design in Photopharmacology with Molecular Photoswitches
University of Groningen · University Medical Center Groningen
Abstract
Photopharmacology is an attractive approach for achieving targeted drug action with the use of light. In photopharmacology, molecular photoswitches are introduced into the structure of biologically active small molecules to allow for the optical control of their potency. Going beyond trial and error, photopharmacology has progressively applied rational drug design methodologies to devise light-controlled bioactive ligands. In this review, we categorize photopharmacological efforts from the standpoint of medicinal chemistry strategies, focusing on diffusible photochromic ligands modified with photoswitches that operate through E-Z bond isomerization. In the vast majority of cases, photoswitchable ligands are…
Citation impact
- FWCI
- 20.51
- Percentile
- 100%
- References
- 265
Authors
4Topics & keywords
- Rational design
- Photochromism
- Nanotechnology
- Combinatorial chemistry
- Drug design
- Computer science
- Chemistry
- Biochemical engineering
- Good health and well-being