reviewAntioxidantsApr 9, 2023GOLD OA

Oxidative Stress, Inflammation and Colorectal Cancer: An Overview

ABAnnamária BardelčíkováJŠJindřich ŠoltýsJMJán Mojžíš

University of Pavol Jozef Šafárik · Institute of Parasitology of the Slovak Academy of Sciences

PubMed
Indexed incrossrefdoajpubmed

Abstract

Colorectal cancer (CRC) represents the second leading cause of cancer-related deaths worldwide. The pathogenesis of CRC is a complex multistep process. Among other factors, inflammation and oxidative stress (OS) have been reported to be involved in the initiation and development of CRC. Although OS plays a vital part in the life of all organisms, its long-term effects on the human body may be involved in the development of different chronic diseases, including cancer diseases. Chronic OS can lead to the oxidation of biomolecules (nucleic acids, lipids and proteins) or the activation of inflammatory signaling pathways, resulting in the activation of several transcription factors or the dysregulation of gene and…

Citation impact

185
total citations
FWCI
18.97
Percentile
100%
References
160
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • Colorectal cancer
  • Inflammation
  • Mouse model of colorectal and intestinal cancer
  • Cancer
  • Oxidative stress
  • Medicine
  • Pathogenesis
  • Disease
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding