The evolution of non-small cell lung cancer metastases in TRACERx
The Francis Crick Institute · Cancer Research UK · +65 more institutions
Abstract
. We report the longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from 421 prospectively recruited patients in TRACERx who developed metastatic disease, compared with a control cohort of 144 non-metastatic tumours. In 25% of cases, metastases diverged early, before the last clonal sweep in the primary tumour, and early divergence was enriched for patients who were smokers at the time of initial diagnosis. Simulations suggested that early metastatic divergence more frequently occurred at smaller tumour diameters (less than 8 mm). Single-region primary tumour sampling resulted in 83% of late divergence cases being misclassified as early, highlighting the importance of extensive…
Citation impact
- FWCI
- 57.08
- Percentile
- 100%
- References
- 75
Authors
286- MAMaise Al BakirCorresponding
The Francis Crick Institute, Cancer Research UK, London Cancer, CRUK Lung Cancer Centre of Excellence, University College London
- AHAriana Huebner
The Francis Crick Institute, Cancer Research UK, London Cancer, CRUK Lung Cancer Centre of Excellence, University College London
- CMCarlos Martínez‐Ruiz
Cancer Research UK, London Cancer, CRUK Lung Cancer Centre of Excellence, University College London
- KGKristiana Grigoriadis
The Francis Crick Institute, Cancer Research UK, London Cancer, CRUK Lung Cancer Centre of Excellence, University College London
- TBThomas B.K. Watkins
The Francis Crick Institute
Topics & keywords
- Lung cancer
- Cancer
- Cancer research
- Medicine
- Biology
- Oncology
- Internal medicine
- Good health and well-being
Funding
- AAAmerican Association for Cancer Research
- BCBreast Cancer Research Foundation
- LFLUNGevity Foundation
- BABrigham and Women's Hospital
- MGMassachusetts General Hospital
- EIEntertainment Industry Foundation
- AUAarhus Universitet
- AUAarhus Universitetshospital
- IFInstitut for Klinisk Medicin, Aarhus Universitet
- UHUniversity Hospital Southampton NHS Foundation Trust
- FCFrancis Crick Institute
- UHUniversity Hospitals of Leicester NHS Trust
- MFMark Foundation For Cancer ResearchAward: 21-029-ASP
- RFRoyal Free London NHS Foundation Trust
- SBSwansea Bay University Health Board
- CRCancer Research UKAward: ID16584
- NINational Institute for Health and Care Research
- UOUniversity of Leicester
- ICImperial College London
- UCUniversity College LondonAward: UCL/12/0279
- UOUniversity of Manchester
- ECEuropean CommissionAwards: 17,18, 34,35, 22,23, 24,25, 36,37, 57,58, 39,40, 835297
- UOUniversity of Glasgow
- UOUniversity of Aberdeen
- UMUniversiteit Maastricht
- SESemmelweis Egyetem
- KLKU Leuven
- PMPeter MacCallum Cancer Centre
- UZUniversität zu Köln
- ELEötvös Loránd Tudományegyetem
- UKUniversitätsklinikum Köln
- OIOncode Institute
- UOUniversity of Texas MD Anderson Cancer Center
- SUStand Up To CancerAwards: SU2C-AACR-DT23-17, AACR-DT23-17
- MRMedical Research CouncilAwards: MR/W025051/1, MR/V033077/1, MR/T02481X/1
- CSCARIM School for Cardiovascular Diseases, Universiteit Maastricht
- BIBeatson Institute for Cancer Research