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RETRACTED ARTICLE: Antibodies against endogenous retroviruses promote lung cancer immunotherapy
The Francis Crick Institute · Cancer Research UK · +72 more institutions
Abstract
Abstract B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS) 1,2 . Although TLS have been found to correlate with improved patient survival and response to immune checkpoint blockade (ICB), the underlying mechanisms of this association remain elusive 1,2 . Here we investigate lung-resident B cell responses in patients from the TRACERx 421 (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy) and other lung cancer cohorts, and in a recently established immunogenic mouse model for lung adenocarcinoma 3 . We find that both human and mouse lung adenocarcinomas elicit local germinal centre responses and…
Citation impact
- FWCI
- 38.18
- Percentile
- 100%
- References
- 71
Authors
331- KWKevin W. NgCorresponding
The Francis Crick Institute
- JBJesse Boumelha
The Francis Crick Institute
- KSKatey S.S. Enfield
The Francis Crick Institute
- JAJorge Almagro
The Francis Crick Institute
- HCHongui Cha
Cancer Research UK, Samsung Medical Center, London Cancer, CRUK Lung Cancer Centre of Excellence, University College London, Sungkyunkwan University
Topics & keywords
- Antibody
- Immunotherapy
- Endogenous retrovirus
- Virology
- Lung cancer
- Cancer immunotherapy
- Immunology
- Endogeny
- Good health and well-being