Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis
National University of Singapore · Shandong First Medical University · +5 more institutions
Abstract
Milk-derived extracellular vesicles (mEVs) have been proposed as a potential nanomedicine for intestinal disorders; however, their impact on intestinal barrier integrity in gut inflammation and associated metabolic diseases has not been explored yet. Here, mEVs derived from bovine and human breast milk exert similar protective effects on epithelial tight junction functionality in vitro, survive harsh gastrointestinal conditions ex vivo, and reach the colon in vivo. Oral administration of mEVs restores gut barrier integrity at multiple levels, including mucus, epithelial, and immune barriers, and prevents endotoxin translocation into the liver in chemical-induced experimental colitis and diet-induced…
Citation impact
- FWCI
- 28.90
- Percentile
- 100%
- References
- 67
Authors
22- LTLingjun TongCorresponding
National University of Singapore, Shandong First Medical University, Ocean University of China
- SZSitong ZhangCorresponding
National University of Singapore
- QLQiqi Liu
Ocean University of China
- CHChenyuan Huang
National University of Singapore
- HHHaining Hao
Ocean University of China
Topics & keywords
- Ex vivo
- Tight junction
- Inflammation
- Steatohepatitis
- Mucus
- Intestinal epithelium
- Immune system
- In vivo
- Good health and well-being
Funding
- LFLee Foundation
- NUNational University of SingaporeAwards: MOE Tier 1, NUHSRO/2020/002/NanoNash/LOA, NUHSRO/2021/034/TRP/09/ Nanomedicine
- NNNational Natural Science Foundation of ChinaAwards: 32172180, FY2021
- MOMinistry of Education, India
- NSNatural Science Foundation of Shandong ProvinceAward: ZR2020KC009
- SFShandong First Medical UniversityAward: 001003130 185RC
- SAShandong Academy of Medical Sciences