Patient-derived xenograft models in cancer therapy: technologies and applications
Central South University · Xiangya Hospital Central South University · +3 more institutions
Abstract
Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted into immunocompromised or humanized mice, have shown superiority in recapitulating the characteristics of cancer, such as the spatial structure of cancer and the intratumor heterogeneity of cancer. Moreover, PDX models retain the genomic features of patients across different stages, subtypes, and diversified treatment backgrounds. Optimized PDX engraftment procedures and modern technologies such as multi-omics and deep learning have enabled a more comprehensive depiction of the PDX molecular landscape and boosted the utilization of PDX models. These irreplaceable advantages make PDX models an ideal choice in cancer…
Citation impact
- FWCI
- 90.71
- Percentile
- 100%
- References
- 311
Authors
6- YLYihan LiuCorresponding
Central South University, Xiangya Hospital Central South University
- WWWantao Wu
Central South University, Xiangya Hospital Central South University
- CCChangjing Cai
Central South University, Xiangya Hospital Central South University
- HZHao Zhang
Dalian Medical University, Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University
- HSHong Shen
Central South University, Xiangya Hospital Central South University
Topics & keywords
- Cancer
- Precision medicine
- Medicine
- Immunotherapy
- Computational biology
- Cancer therapy
- Clinical trial
- Cancer treatment
- Good health and well-being