Single-shot isotropic differential interference contrast microscopy
Nanyang Technological University · Harbin Institute of Technology · +9 more institutions
Abstract
Differential interference contrast (DIC) microscopy allows high-contrast, low-phototoxicity, and label-free imaging of transparent biological objects, and has been applied in the field of cellular morphology, cell segmentation, particle tracking, optical measurement and others. Commercial DIC microscopy based on Nomarski or Wollaston prism resorts to the interference of two polarized waves with a lateral differential offset (shear) and axial phase shift (bias). However, the shear generated by these prisms is limited to the rectilinear direction, unfortunately resulting in anisotropic contrast imaging. Here we propose an ultracompact metasurface-assisted isotropic DIC (i-DIC) microscopy based on a grand…
Citation impact
- FWCI
- 33.92
- Percentile
- 100%
- References
- 52
Authors
19- XWXinwei WangCorresponding
Nanyang Technological University, Harbin Institute of Technology
- HWHao Wang
Singapore University of Technology and Design
- JWJinlu Wang
Harbin Medical University, Third Affiliated Hospital of Harbin Medical University
- XLXingsi Liu
National University of Singapore
- HHHuijie Hao
Harbin Institute of Technology
Topics & keywords
- Differential interference contrast microscopy
- Optics
- Microscopy
- Interference microscopy
- Optical microscope
- Isotropy
- Materials science
- Interference (communication)