Ageing-associated changes in transcriptional elongation influence longevity

Debès, Cédric; Papadakis, Antonios; Grönke, Sebastian; Karalay, Özlem; Tain, Luke S.; Mizi, Athanasia; Nakamura, Shuhei; Hãhn, Oliver; Weigelt, Carina Marianne; Josipović, Nataša; Zirkel, Anne; Brusius, Isabell; Sofiadis, Konstantinos; Lamprousi, Mantha; Lu, Yuxuan; Huang, Wenming; Esmaillie, Reza; Kubacki, Torsten; Späth, Martin R.; Schermer, Bernhard; Benzing, Thomas; Müller, Roman‐Ulrich; Antebi, Adam; Partridge, Linda; Papantonis, Argyris; Beyer, Andreas

doi:10.1038/s41586-023-05922-y

articleNatureApr 12, 2023HYBRID OA

Ageing-associated changes in transcriptional elongation influence longevity

CDCédric Debès APAntonios Papadakis SGSebastian Grönke ÖKÖzlem Karalay LSLuke S. Tain

University of Cologne · Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases · +6 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Abstract Physiological homeostasis becomes compromised during ageing, as a result of impairment of cellular processes, including transcription and RNA splicing 1–4 . However, the molecular mechanisms leading to the loss of transcriptional fidelity are so far elusive, as are ways of preventing it. Here we profiled and analysed genome-wide, ageing-related changes in transcriptional processes across different organisms: nematodes, fruitflies, mice, rats and humans. The average transcriptional elongation speed (RNA polymerase II speed) increased with age in all five species. Along with these changes in elongation speed, we observed changes in splicing, including a reduction of unspliced transcripts and the…

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Topics & keywords

Topics

Keywords

Ageing
Biology
RNA polymerase II
Transcription (linguistics)
Cell biology
RNA splicing
Polymerase
Longevity

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