Piezoelectric Metal–Organic Frameworks Based Sonosensitizer for Enhanced Nanozyme Catalytic and Sonodynamic Therapies
Dalian University of Technology · Dalian University · +2 more institutions
Abstract
The regulation of electrostatic electric fields through electrical stimulation is an efficient method to increase the catalytic activity of nanozymes and improve the therapeutic effect of nanozyme catalytic therapy. Piezoelectric materials, which are capable of generating a built-in electric field under ultrasound (US), not only improve the activity of nanozymes but also enable piezoelectric sonodynamic therapy (SDT). In this study, a sonosensitizer based on a Hf-based metal–organic framework (UIO-66) and Au nanoparticles (NPs) was produced. Under US irradiation, UIO-66 can generate a built-in electric field inside the materials, which promotes electron–hole separation and produces reactive oxygen species…
Citation impact
- FWCI
- 20.29
- Percentile
- 100%
- References
- 48
Authors
10- LCLihan Cai
Dalian University of Technology, Dalian University
- JDJianjun DuCorresponding
Ningbo University, Ningbo University of Technology, Dalian University of Technology, Dalian University
- FHFuping Han
Dalian University of Technology, Dalian University
- TSTiancong Shi
Dalian University of Technology, Dalian University
- HZHan Zhang
Dalian University of Technology, Dalian University
Topics & keywords
- Piezoelectricity
- Sonodynamic therapy
- Materials science
- Electric field
- Reactive oxygen species
- Nanoparticle
- Nanotechnology
- Chemistry