reviewFrontiers in Bioengineering and BiotechnologyApr 13, 2023GOLD OA

Advances in nanomaterial-based targeted drug delivery systems

XCXiaoxiao ChengQXQirong XieYSYang Sun

Dalian Medical University · Second Affiliated Hospital of Chongqing Medical University · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and biological properties. By combining therapeutic drugs with nanoparticles using rational targeting pathways, nano-targeted delivery systems were created to overcome the main drawbacks of conventional drug treatment, including insufficient stability and solubility, lack of transmembrane transport, short circulation time, and undesirable toxic effects. Herein, we reviewed the recent developments in different targeting design strategies and therapeutic approaches employing various nanomaterial-based systems. We also discussed the challenges…

Citation impact

340
total citations
FWCI
32.18
Percentile
100%
References
287
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • Drug delivery
  • Targeted drug delivery
  • Drug
  • Nanotechnology
  • Systemic circulation
  • Pharmacology
  • Medicine
  • Materials science
UN Sustainable Development Goals
  • Good health and well-being
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