articleJournal of the American Chemical SocietyApr 14, 2023Closed access

Multi-enzyme Co-expressed Dual-Atom Nanozymes Induce Cascade Immunogenic Ferroptosis via Activating Interferon-γ and Targeting Arachidonic Acid Metabolism

YLYang LiuRNRui NiuRDRuiping DengSSShuyan SongYWYinghui Wang

Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Immunotherapy is currently the most promising treatment strategy for long-term tumor regression. However, current cancer immunotherapy shows low response rates due to insufficient immunogenicity of tumor cells. Herein, we report a strategy to keep tumor cells highly immunogenic by triggering cascade immunogenic tumor ferroptosis. We developed a six-enzyme co-expressed nanoplatform: lipoxygenase (LOX) and phospholipase A2 (PLA2)-co-loaded FeCo/Fe–Co dual-metal atom nanozyme (FeCo/Fe–Co DAzyme/PL), which can not only induce initial immunogenic tumor ferroptosis through its own multi-enzyme mimetic activities but also up-regulate arachidonic acid (AA) expression to synergize with CD8+ T cell-derived IFN-γ to…

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186
total citations
FWCI
44.91
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100%
References
45
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Authors

6

Topics & keywords

Topics
Keywords
  • Chemistry
  • Arachidonic acid
  • Cancer research
  • Reactive oxygen species
  • Enzyme
  • GPX4
  • Phospholipase A2
  • Immunogenic cell death
UN Sustainable Development Goals
  • Good health and well-being
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