articleNatureApr 13, 2023HYBRID OA

Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA

CAChristopher AbboshAMAlexander M. FrankellTHThomas HarrisonJKJudit KisistókATAaron T. Garnett

Cancer Research UK · London Cancer · +70 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Circulating tumour DNA (ctDNA) can be used to detect and profile residual tumour cells persisting after curative intent therapy1. The study of large patient cohorts incorporating longitudinal plasma sampling and extended follow-up is required to determine the role of ctDNA as a phylogenetic biomarker of relapse in early-stage non-small-cell lung cancer (NSCLC). Here we developed ctDNA methods tracking a median of 200 mutations identified in resected NSCLC tissue across 1,069 plasma samples collected from 197 patients enrolled in the TRACERx study2. A lack of preoperative ctDNA detection distinguished biologically indolent lung adenocarcinoma with good clinical outcome. Postoperative plasma analyses were…

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Topics & keywords

Topics
Keywords
  • Lung cancer
  • Tracking (education)
  • Oncology
  • Cancer research
  • Medicine
  • Computational biology
  • Internal medicine
  • Biology
UN Sustainable Development Goals
  • Good health and well-being
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