Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration

Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable drug delivery, and diverse cargo loading capacity. Although microneedles are initially designed to penetrate stratum corneum of skin for transdermal drug delivery, they, recently, have been used to promote wound healing and regeneration of diverse tissues and organs and the results are promising. Despite there are reviews about microneedles, few of them focus on wound healing and tissue regeneration. Here, we review the recent advances of microneedles in this field. We first give an overview of microneedle system in terms of its potential cargos (e.g.,…

• NN
  National Natural Science Foundation of China

  Awards: U1909218, T2121004, 82122002
• SF
  Science Fund for Creative Research Groups

  Award: T2121004
• HK
  Hong Kong Polytechnic University

  Award: P0039523
• YS
  Young Scientists Fund
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Award: 2020B1515130002