Cellular Senescence in Intervertebral Disc Aging and Degeneration: Molecular Mechanisms and Potential Therapeutic Opportunities
University of Pittsburgh · University of California, Los Angeles · +1 more institution
Abstract
Closely associated with aging and age-related disorders, cellular senescence (CS) is the inability of cells to proliferate due to accumulated unrepaired cellular damage and irreversible cell cycle arrest. Senescent cells are characterized by their senescence-associated secretory phenotype that overproduces inflammatory and catabolic factors that hamper normal tissue homeostasis. Chronic accumulation of senescent cells is thought to be associated with intervertebral disc degeneration (IDD) in an aging population. This IDD is one of the largest age-dependent chronic disorders, often associated with neurological dysfunctions such as, low back pain, radiculopathy, and myelopathy. Senescent cells (SnCs) increase in…
Citation impact
- FWCI
- 43.77
- Percentile
- 100%
- References
- 196
Authors
7Topics & keywords
- Senescence
- Degeneration (medical)
- Oxidative stress
- Inflammation
- Population
- Phenotype
- Medicine
- Intervertebral disc
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